The paper presents the results of research on the influence of granulated blast furnace slag, natural pozzolana [superzeolite], and limestone powder on the performance of multi-component cements. It was found that the synergistic combination of mineral additives of different genesis, taking into account the influence of the particle size distribution [PSD] by volume and surface area, as well as the determination of indicators of the influence of physical factors such as water demand, bleeding, pozzolanic activity, the heat of hydration on the set of properties of paste and concrete: workability, standard, and early strength, global warming potential, allows to obtain technologically optimized multi-component Portland cements. The results showed that the production of multi-component Portland cement with high early strength CEM II/B-M 42.5 R-LH ensures separate grinding of individual constituents, optimization of grain composition of slag, superzeolite, and limestone powder taking into account the PSD by surface area.